Role of polymerase β in DNA metabolism and genomic instability |
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| Authors: | WANG Gu-liang YU Ying-nian |
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| Institution: | Department of Pathophysiology, Medical school of Zhejiang University, Hangzhou 310031, China |
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| Abstract: | The major role of DNA polymerase β was thought to be limited in its involvement in short patch base excision repair by removing 5’-deoxyribose phosphate and base insertion. However, the recent researches indicate that polymerase β might take part in a wide spectrum of DNA metabolism reactions, including long patch base excision repair, DNA replication, recombination, meiosis and transleisional DNA synthesis. Because of its wide and important cellular function, an inappropriate intracellular polymerase β level might be associated with genomic instability. Down-regulation or mutation of polymerase β is mutagenic due to deficient in DNA repair, while overexpression of this error-prone β polymerase might perturb the normal function of other accurate polymerases and cause genomic instability as well. |
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| Keywords: | DNA polymerase β base excision repair DNA replication DNA recombinant Genomic instability |
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