The comparative study on SiNi-decoction and VitE against oxidative injury of vascular endothelial function and their preventive and therapeutic action on experimental atherosclerosis in rabbits |
| |
| Authors: | HUANG He-qing WU Wei-kang LUO Han-chuan |
| |
| Institution: | Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China |
| |
| Abstract: | AIM: To compare effects of SiNi-decoction and Vitamin E on vascular endothelial function of experimental atherosclerosis rabbits and their therapeutic action on atherosclerosis.METHODS:The model of experimental atherosclerosis rabbits fed with forage of high lipid was established and treated in groups randomly. At the end of the experiment, samples of aorta and blood were taken and the percentage of lipid plaque area of aortic endothelium ,lipid metabolism and vascular endothelial oxidative injury (SOD activity, MDA content, NO level, endothelin concentration) of each group were analyzed. RESULTS: In comparison with model group,the percentage of the lipid plaque area of aortic endothelium and endothelial oxidative injury (except for SOD of VitE group) of SiNi-high and mid-dose group and VitE group are reduced obviously (P＜0.05),and the index of lipid metabolism of SiNi-decoction group is improved (P＜0.05). CONCLUSION:The comprehensive therapentic effects of SiNi decoction on vascular endothelial oxidative injury and atherosclerosis are superior to VitE. |
| |
| Keywords: | Atherosclerosis Endothelium vascular Wounds and injuries Drugs Chinese herbal Vitamin E |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|
