Changes of plasma endostatin levels in nude mice bearing human nasopharyngeal carcinoma |
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| Authors: | YANG Hui-ling SHE Miao-rong MA Zhi-kai GUO Hui ZHENG Qin SU Xiu-rong |
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| Institution: | 1. Department of Pathophysiology, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China;
2. Department of Haematology, Guangdong Provincial People's Hospital,Guangzhou 510080,China;
3. Cancer Center,Sun Yat-sen University of Medical Sciences,Guangzhou 510089,China |
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| Abstract: | AIM: To approach the changes of endostatin levels in BALB/c nude mice bearing human nasopharyngeal carcinoma(NPC) in different period (5, 10, 20, 30 and 40 days) and the relationship between endostatin and tumor's development. METHODS: BALB/c nude mice bearing NPC was reproduced by hypodermic implantation of human CNE-2 cells into right-side of axillary fossa. The level of plasma endostation was detected, and the weight of isolated tumors was measured. On the basis of the regulation of these changes, their relationships were explored. RESULTS: At 5 days (137.61±53.41) μg/L] or 10 days (103.06±17.33) μg/L] endostatin level had no apparent alternation in comparison with control group (113.56±21.74) μg/L, P>0.05]. At 20, 30 and 40 days concentration of endostatin(212.80±85.91) μg/L,(293.63±62.53) μg/L, (271.57±32.45) μg/L, respectively] were higher than that of the control group (P<0.05). Along with the development of the tumors, both the levels of endostatin and tumors weight increased. There was a positive correlation between the level of endostatin and tumor weight (r=0.687, P<0.05). CONCLUSION:These results suggested that endostatin links with the development of NPC. |
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| Keywords: | Nasopharyngeal neoplasms Endostatin Mice nude |
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