Alteration of functional receptors in heart for human urotensin II in pressure overload- induced cardiac hypertrophy of rats |
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| Authors: | ZHANG Yong-gang YANG Jun WANG Xiao-hong FU Min-gui ZHANG Ying TANG Chao-shu |
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| Institution: | Department of Cardiovascular Research, the First Hospital, Peking University, Beijing 100034 |
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| Abstract: | AIM:To investigate alteration of functional receptors for urotensin II in pressure overload-induced cardiac hypertrophy of rats. METHODS: In the rat cardiac hypertrophy model produced by constriction of the abdominal aorta, urotensin II binding sites in myocardial sarcolemma were determined with radioligand assay first day (early group) and 30th day (late group) after operation. RESULTS:Compared with control and sham group, in the early group,the blood pressure increased 54% and 43% respectively(P＜0.01),and heart/body weight ratio unchanged(P＞0.05),UII receptors were up-regulated by 184% and 159%(P＜0.01)respectively, While the affinity to UII was decreased (Kd increased 224% and 206 respectively,P＜0.01).In the late group, the blood pressure increased 85% and 67% (P＜0.01), and heart/body weight ratio increased 18% and 22% (P＜0.05) respectively,than that of control and sham group. UII receptors were down-regulated by 35% and 41%(P＜0.05) respectively while the affinity to UII was increased (Kd decreased 30% and 33% respectively, P＜0.05). CONCLUSION: The biphasic changes of UII receptor in myocardial sarcolemma induced by pressure-overload were observed,increasing in early stage, while decreasing in late stage, and these changes were involved in the development of cardiac hypertrophy. |
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| Keywords: | Urotensins Myocardium Hypertrophy |
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