Effect of bFGF on expression of endothelial cell integrin β1 subunits |
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| Authors: | ZHOU Xu-long DENG Yi-ping |
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| Institution: | 1. Dept. of Pathology, Medical College of Jinan University, Guangzhou 510632, China;
2. Dept. of Histology and Embryology, Sun Yat-Sen University of Medical Science, Guangzhou 510089, China |
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| Abstract: | AIM: To study the effect of basic fibroblast growth factor(bFGF) to the expression of integrin β1 subunit of endothelial cells. METHOD: The expression of integrin β1 subunit of endothelial cells was determined before and after bFGF treatment with Western Blot and immage analysis method.RESULTS: The mean gray value of immunostain by immage analysis method is 166.11±9.86 in the experimental group and 175.32±5.12 in the control group, suggested that bFGF may upregulate expression of integrin β1 subunits of endothelial cell. CONCLUSION: bFGF may play an important role in angiogenesis by way of inducing the overexpression of endothelial cell integrin β1 subunits. |
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| Keywords: | Fibroblast growth factor basic Integrins Neovascularization |
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