Insulin influences the vasoconstriction caused by endothelin-1 in the hyperglycemic rat |
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| Authors: | DING Yi WANG Jia-fu LIU Tong-mei DUAN Wen-zuo SONG Xiu-yuan GONG Jian-ling |
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| Institution: | Department of Pathophysiolgy, Weifang Medical College, Weifang 261042, China |
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| Abstract: | AIM: To investigate the effects of insulin on aortic constriction caused by endothelin-1(ET-1) in normal and hyperglycemic rats. METHODS: Hyperglycemic rat models were prepared. Two aortic rings were immersed in the Krebs-Hensleit fluid with and without insulin (40 mIU/L) and the responses of rings to 10-9 mol/L ET-1 were observed. RESULTS:ET-1 induced more obvious aortic ring constriction in normal rats than those in hyperglycemic rats ( P< 0.01). Rings constriction caused by ET-1 were attenuated in normal rats if the rings were immersed in the KH fluid with insulin ( P< 0.01), but no obvious changes were found in hyperglycemic rats.CONCLUSION: (1) the vasoconstriction of aortic rings caused by ET-1 can be reduced by hyperglycemia. (2) Insulin can attenuate the aortic response to ET-1. (3) Insulin can not attenuate the vasoconstriction caused by ET-1 in hyperglycemic rats. These results suggest that insulin may affect vasoconstriction caused by ET-1, which may be involved in the pathogenesis of vascular complication in diabetic or insulin resistance condition. |
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| Keywords: | Insulin Endothelins Aorta Hyperglycemia |
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