Study on the relationship between melatonin and hepatic encephalopathy |
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| Authors: | WU Wan-chun ZHANG Guo-zheng WANG Yu-xiang HE Chi-yi |
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| Institution: | The Digestive Department, Yijishan hospital of Wannan medical college, Wuhu 241001, China |
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| Abstract: | AIM:To explore the relationship between change of serum melatonin (MT) and pathogenesis of hepatic encephalopathy (HE). METHODS: Changes of MT level in sera of cirrhosic patients with HE and without HE were determined by ELISA, normal serum served as control. The change of serum MT level in exacerbation and remission in HE was also determined.RESULTS:MT level in patients with HE was higher than that withour HE (P＜0.01). MT levels of both groups were higher than that of normal group (P＜0.01). They were (308.53±59.07) ng/L, (139.85±34.59)ng/L,(77.73±28.41)ng/L, respectively. Serum MT level in exacerbation was higher than that in remission (P＜0.01), they were (301.52±66.42)ng/L and (147.81±23.31) ng/L, respectively. CONCLUSION: The elevation of MT content in sera may be closely related to the onset of hepatic coma. |
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| Keywords: | Melatonin Hepatic encephalopathy Liver cirrhosis |
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