Role of K+ channels in attenuation of pulmonary vasoreactivity following chronic hypobaric hypoxia in rats |
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| Authors: | HONG Zhi-gang WANG Di-xun HU Qing-hua CHEN Qi-ling SUN Bing-yong |
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| Institution: | 1.Key Lab of Pulmonary Diseases of Ministry of Health, Tongji Medical University, Wuhan 430030, China;2.Department of Pathophysiology, Third Military Medical University, Chongqing 630038, China |
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| Abstract: | AIM and METHODS: To determine the role of different K+-channels in attenuation of vasoreactivity of intrapulminary artery rings induced by chronic hypoxia. RESULTS: ①Acute hypoxia-induced pulmonary vasoconstriction (HPV) could be significantly attenuated by chronic hypobaric hypoxia for 15 days and for 30 days. ②HPV could be significantly potentiated by ATP-sensitive K+-channel (KATP) blocker or Ca2+-activated K+-channel (KCa) blocker, and the potentiated scope in chronic hypoxic group was much higher than that observed in control group. ③Delayed rectifier K+-channel (KDR) blocker showed no effect on HPV in both control group and chronic hypoxic group. CONCLUSION: Both KATP and KCa play an important modulating role in HPV and its potentiation may be a critical mechanism for the attenuated vasoreactivity to acute hypoxia following chronic hypobaric hypoxia. |
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| Keywords: | Anoxia Pulmonary artery Potassium channels |
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