XBP-01 accelerated apoptosis induced by oxidized low density lipoprotein in vascular smooth muscle cells |
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| Authors: | YUAN Zhong-hua YANG Yong-zong YANG Xiao-yi TAN Jian-miao WAN Zai-yang |
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| Institution: | Institute of Cardiovascular Disease of Hengyang Medical College, Hengyang 421001,China |
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| Abstract: | AIM: Previous studies performed with XBP-01 in vitro indicated that XBP-01 could inhibit vascular smooth muscle cells from being transformed into foam cell and could eliminate the atherosclerotic plaque in C57BL/6J mouse. This experiment is to investigate its mechanism of eliminating plaques in vitro. METHODS: The cultured porcine artery smooth muscle cells incubated with XBP-01 of 0.1 mg/L for 24 h after preincubated with oxidized low density lipoprotein of 15 mg/L for 72 h in vitro. The samples were analyzed by fluorescence microscope, confocal microscope system and flow cytometry. RESULTS: Apoptosis was triggered by being incubated with oxidized low density lipoprotein and this process was accelerated additionally by being incubated with XBP-01. CONCLUSION: XBP-01 can be effective in eliminating atherosclerotic plaque by accelerating the process in which oxidized low density lipoprotein induced smooth muscle cell apoptosis. |
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| Keywords: | Peptides Lipoproteins LDL Muscle smooth vascular Cells Apoptosis |
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