Protective effect of Ligustrazini on gut barrier function |
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| Authors: | WANG Wan-tie XU Zheng-jie LIN Li-na WANG Wei LI Dong WANG Zong-min |
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| Institution: | 1. Department of Pathophysiology Wenzhou Medical College, Wenzhou 325027,China;
2. First Affiliated Hospital Wenzhou Medical College, Wenzhou 325027,China;
3. Department of Clinical Laboratory Medicine Wenzhou Medical College, Wenzhou 325027,China;
4. Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027,China |
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| Abstract: | AIM:To study the protective effect of Ligustrazini(LGT) on gut barrier function after hemorrhagic shock-reperfusion. METHODS: Thirty white rabbits were divided randomly into 3 groups: control group (A),shock group (B) and LGT group (C). Malondialdehyde(MDA), tumor necrosis factor-α(TNFα), interleukin-1β(IL-1β) and nitric oxide products(NO2-/NO3-) contents were measured in intestinal mucosa at 3 hours following reperfusion,culture of bacteria in blood from rabbits of 3 groups was carried out,the intestinal mucosa was examined under optical and electron microscope. RESULTS: MDA, TNFα, IL-1β and NO2-/NO3- contents of intestinal mucosa remained unchanged in group C,but increased significantly in group B, compared with group A. Incidence of bacterial translocation in group B was markedly higher than that in group A at 30 min following reperfusion,there was not any difference between group A and group C. Under light and electronic microscope,in comparison with A and C groups,intestinal mucosa damage in B group became more severe. CONCLUSION: LGT can protect gut barrier from intestinal ischemia-reperfusion injury induced by hemorrhagic shock through reducing oxygen free radicals,raising nitric oxide and preventing inflammation. |
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| Keywords: | Shock hemorrhagic Intestinal mucosa Drugs Chinese herbal |
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