The antioxidative activity of a new compound from ginger |
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| Authors: | HE Wen-shan LI Lin LI Yan GUO Si-yuan GUO Bao-jiang |
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| Institution: | 1. Department of Biochemistry, Medical College, Jinan University, Guangzhou 510632, China;
2. nstitute of Light Industry & Chemical Engineer, South China University of Technology, Guangzhou 510641, China;
3. epartment of Chemistry, Jinan University, Guangzhou 510632, China;
4. Institute of Biologic Technology, South China Normal University, Guangzhou 510631, China |
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| Abstract: | AIM:To assess the antioxidative activity of a new cyclic diaryheptanoid (compound 1) from ginger on free radical damage. METHODS: Hemolysis, MDA levels of mice liver tissue homogenates, the conformation changes of irradiated PUC18 were used as indices. RESULTS:Compound 1 significantly reduced the hemolysis of human red blood cells induced by H2O2 (P＜0.01) and MDA level in the liver of mice (P＜0.01), raised the percentage of the supercoil conformation of plasmid PUC18 induced by60Co]γ-rays (P＜0.05 or P＜0.01).CONCLUSION:Compound 1 had a good activity on suppressing oxygen free radical damage. |
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| Keywords: | Ginger Cyclic diaryheptanoid Hemolysis Lipid peroxides Plasmids |
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