Analgesic sesquiterpene dilactone from Mikania cordata. |
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| Authors: | M Ahmed M T Rahman M Alimuzzaman J A Shilpi |
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| Institution: | Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. phardu@citechco.net |
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| Abstract: | The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity. |
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