Effects of steroid hormones on immunoglobulin M (IgM) in rainbow trout, Oncorhynchus mykiss |
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| Authors: | YY Hou Y Suzuki K Aida |
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| Institution: | (1) Department of Aquatic Biosciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113, Japan |
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| Abstract: | The immunosuppressive effects of steroid hormones were evaluated as the response against implanted steroid hormones, cortisol (F), testosterone (T), estradiol-17 (E2), and 11- ketotestosterone (11-KT), in juvenile rainbow trout. In long term experiments (5 weeks), fish were given a single intraperitoneal implant of F or T. A clear suppressive effect of plasma IgM levels with F and T was not necessarily obtained, although mucus IgM levels were reduced corresponding to the elevated plasma steroid hormone levels. In short term experiments (1 week), intraperitoneal implantation of T, 11-KT and E2 suppressed plasma and mucus IgM levels, although the effects were not dose-dependent. When administered through diet, F and T caused a suppression of plasma IgM levels; F administration at both high and low dosages caused a significant decrease in plasma IgM levels, while only a high dose of T caused the suppression. These results suggest that sex steroid hormones, as well as F, have immunosuppressive functions in rainbow trout. |
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| Keywords: | cortisol estradiol-17 " target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0"> 11-ketotestosterone mucus plasma testosterone |
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