| 猪内服和静脉给予多西环素的药代动力学研究 |
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| 引用本文： | 魏丽娟,贾 兴.猪内服和静脉给予多西环素的药代动力学研究[J].中国兽药杂志,2017,51(9):24-29. |
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| 作者姓名： | 魏丽娟 贾 兴 |
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| 作者单位： | 河北远征药业有限公司,河北远征药业有限公司 |
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| 摘 要： | 建立了超高效液相色谱-串联质谱法测定猪血浆中多西环素的浓度,探讨了猪内服和静脉给予多西环素水溶液后的药代动力学特征。结果表明：猪单次内服10 mg.kg-1体重多西环素饮水剂型水溶液后,MRTlast为12.82±3.34 h,T1/2为11.65±4.80 h,Tmax为4.13±1.89 h,Cmax为0.87±0.48 μg.mL-1,AUClast为11.07±4.19μg.h.mL-1。猪静注10 mg.kg-1体重多西环素水溶液后,AUClast为33.34±8.03μg.h.mL-1,T1/2为5.68±1.32 h,MRTlast为7.98±0.56 h。多西环素饮水剂水溶液的绝对生物利用度为33.2%。猪内服多西环素饮水剂后,具有体内吸收速度较快,达峰时间短,消除较慢,血中平均滞留时间较长等特点。
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| 关 键 词： | 多西环素饮水剂 超高效液相色谱-串联质谱 药代动力学 猪 |
| 收稿时间： | 2017/4/13 0:00:00 |
| 修稿时间： | 2017/8/16 0:00:00 |
Pharmacokinetics of Doxycycline in swine after Oral and Intravenous Administration |
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| Institution: | Hebei Yuanzhoang Phamaceutical CO,LTD, |
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| Abstract: | An UPLC-MS/MS method was established for the detection of concentration of doxycycline in porcine plasma. The pharmacokinetis of oral and intravenous doxycycline were investigated in pig. The results demonstrated that: At a single oral dose of 10 mg ? kg-1 body weight of doxycycline drinking water, MRTlast = 12.82±3.34 h, T1/2 = 11.65±4.80 h, Tmax = 4.13± |
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| Keywords: | Doxycycline Drinking Water UPLC-MS/MS Pharmacokinetics Swine |
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