Hypercalcemia and high parathyroid hormone-related peptide concentration in a dog with a complex mammary carcinoma |
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| Authors: | Bae Bo-kyoung Kim Chae-wook Choi Ul-soo Choi Eun-wha Jee Hyang Kim Dae-yong Lee Chang-woo |
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| Institution: | Department of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea. |
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| Abstract: | A 10-year-old female Dachshund was presented with a history of mammary masses, slight lethargy, polyuria, and polydipsia. Physical examination findings included masses involving the first, second, and fourth mammary glands of the left side. The mandibular, axillary, and right popliteal lymph nodes were mildly enlarged. Serum chemistry results included hypercalcemia (13.9 mg/dL, reference interval 8.0-11.5 mg/dL). Although intact parathyroid hormone (PTH) concentration (1.05 pmol/L) was below the reference interval (2-13 pmol/L), PTH-related protein (PTHrP) concentration was markedly increased (9.40 pmol/L, reference value < 2 pmol/L). The masses were surgically removed, and the histopathologic diagnosis was complex mammary carcinoma. Three weeks after surgery, serum total calcium concentration had decreased to 10.5 mg/dL. Resolution of the hypercalcemia and clinical signs supported a diagnosis of humoral hypercalcemia of malignancy associated with mammary gland carcinoma. |
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| Keywords: | Dog humoral hypercalcemia of malignancy mammary gland tumor parathyroid-hormone–related protein |
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