Humanized mice in infectious diseases |
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| Institution: | 1. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark;2. Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark;3. The hospital Pharmacy at Aarhus University Hospital, Skejby, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark;4. Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark;1. Universität Bielefeld, Fakultät für Chemie, Organische Chemie, Universitätsstr. 25, 33615, Bielefeld, Germany;2. Structure and Function of Biological Membranes, Université Libre de Bruxelles, Belgium;3. Universität Bielefeld, Fakultät für Physik, Universitätsstr. 25, 33615, Bielefeld, Germany |
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| Abstract: | The pathogenesis of infectious agents with human tropism can only be properly studied in an in vivo model featuring human cells or tissue. Humanized mice represent a small animal model featuring human cells or tissue that can be infected by human-specific viruses, bacteria, and parasites and also providing a functional human immune system. This makes the analysis of a human immune response to infection possible and allows for preclinical testing of new vaccines and therapeutic agents. Results of various studies using humanized mice to investigate pathogens with human tropism are presented in this review. In addition, the limitations of humanized mice and methods to improve this valuable animal model are discussed. |
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| Keywords: | Review Humanized mice Infectious diseases Human specific pathogens |
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