Antioxidative and acute antiinflammatory effects of Torreya grandis |
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| Authors: | Chen Bao-Qiong Cui Xiang-Yu Zhao Xin Zhang Yong-He Piao Hui-Shan Kim Jin-Hwa Lee Bum-Chun Pyo Hyeong-Bae Yun Yeo-Pyo |
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| Institution: | Department of Pharmacology, Peking University, School of Basic Medical Science, 38 Xueyuan Lu, Beijing 100083, China. |
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| Abstract: | The present study was undertaken to investigate the antioxidative and antiinflammatory activities of the ethanolic extract of seeds of Torreya grandis (EST). Exposure of human dermal fibroblasts to the extract at 50 and 250 microg/ml showed significant protective effect against hydrogen peroxide (300 microM). EST not only protected cell survival from H(2)O(2)-induced toxicity, but also inhibited the H(2)O(2)-induced LDH release significantly. It was also found that EST at 100 and 1000 microg/ml showed scavenging activities of radicals and reactive oxygen species with 29.8% and 100.0% of inhibition against DPPH radical and 41.2% and 98.4% against superoxide radicals in the xanthine/xanthine oxidase system, respectively. Topically applied EST dose-dependently inhibited arachidonic acid (AA)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. |
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| Keywords: | Torreya grandis Antioxidant activity Human dermal fibroblast Antiinflammatory activity Mice ear edema |
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