| 禽法氏囊三肽囊素免疫生物学及其同功能单链抗体研究进展 |
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| 引用本文： | 邬向东,谌南辉.禽法氏囊三肽囊素免疫生物学及其同功能单链抗体研究进展[J].动物医学进展,2002,23(2):19-21. |
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| 作者姓名： | 邬向东 谌南辉 |
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| 作者单位： | 江西农业大学动物科学技术学院,江西南昌,330045 |
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| 基金项目： | 江西省自然科学基金资助项目 (0 130 0 2 3) |
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| 摘 要： | 法氏囊（BF）是禽类特有的免疫器官，为B细胞发育、成熟提供微环境，是免疫球蛋白基因转变场所；其免疫活性物质为三肽囊素（Bursin)；它不仅分布于BF，还存在于胸腺Hassall小体、哈德氏腺、脾脏、BF T细胞区及骨髓；它能诱导家禽和哺乳动物B细胞前体分化；其靶器官是BF，能够拮抗IBD疫苗对BF的损伤，提高ND弱毒疫苗及油苗产生抗体水平；人工合成Bursin作用的靶器官也是BF，可促进BF发育、抗体的产生、维持母源抗体作用。
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| 关 键 词： | 法氏囊 三肽囊素 单链抗体 禽 研究进展 |
| 文章编号： | 1007-5038(2002)02-0019-03 |
| 修稿时间： | 2001年8月26日 |
The Progress of Study on Avian' s Bursa of Fabricius Bursin Immuno-biology and its Bursin-SCFv |
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| WU Xiang dong,CHEN Nan hui.The Progress of Study on Avian'''' s Bursa of Fabricius Bursin Immuno-biology and its Bursin-SCFv[J].Progress In Veterinary Medicine,2002,23(2):19-21. |
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| Authors: | WU Xiang dong CHEN Nan hui |
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| Abstract: | Bursa of Fabricius is avian endemtic immune organ and it supplies a micro enviroment for the development and maturity of B cell. It's immune competent substance is Bursin , which distributes not only in Bursa of Fabridius but also in Hassall's corpuscle, gland of Harder, spleen , BF T cell region and bone marrow. Bursin can induce the precursor of avian and mammalian B cell to differentiate. Its target organ is BF and can antagonise the injury which IBD vaccine does to BF. Mcreover , Bursin can exalt the antibody level of Newcastle Disease low virulent and oil emulsion adjuvant vaccine. The target organ of chemically synthesis Bursin is also BF. It can enhance the development of BF, the producing of antibody and the maintain the maternal antibody. Since Bird first was reported that E.coli, E can assemble correctly the Fab and Fv Fragment of antibody and keep the specificity of pro antibody in 1980,the construction of Single chain antibody gene by gene engineering technology have developed a mature technology . But it's very rare in the field of veterinary medicine. So the producing of Bursin ScFv by pathogen free pollution should be the goal of this research. |
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| Keywords: | bursa of Fabricius Bursin Single Chain Fv |
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