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Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate |
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| Authors: | Denoeud France Henriet Simon Mungpakdee Sutada Aury Jean-Marc Da Silva Corinne Brinkmann Henner Mikhaleva Jana Olsen Lisbeth Charlotte Jubin Claire Cañestro Cristian Bouquet Jean-Marie Danks Gemma Poulain Julie Campsteijn Coen Adamski Marcin Cross Ismael Yadetie Fekadu Muffato Matthieu Louis Alexandra Butcher Stephen Tsagkogeorga Georgia Konrad Anke Singh Sarabdeep Jensen Marit Flo Cong Evelyne Huynh Eikeseth-Otteraa Helen Noel Benjamin Anthouard Véronique Porcel Betina M Kachouri-Lafond Rym Nishino Atsuo Ugolini Matteo Chourrout Pascal Nishida Hiroki Aasland Rein Huzurbazar Snehalata |
| Institution: | Commissariat à l'énergie Atomique, Institut de Génomique, Genoscope, Evry, France. |
| Abstract: | Genomes of animals as different as sponges and humans show conservation of global architecture. Here we show that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retaining chordate morphology. Ancestral architecture of animal genomes can be deeply modified and may therefore be largely nonadaptive. This rapidly evolving animal lineage thus offers unique perspectives on the level of genome plasticity. It also illuminates issues as fundamental as the mechanisms of intron gain. |
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