|
|||||
|
|
| SMM在实验性肾功能损害家兔体内的药物动力学研究 | |
| 引用本文： | 李引乾,蒿彩菊,刘晓强,白东英,佘永新,陶大勇,张江铃,白占明.SMM在实验性肾功能损害家兔体内的药物动力学研究[J].西北农业学报,2006,15(5):6-9. |
| 作者姓名： | 李引乾 蒿彩菊 刘晓强 白东英 佘永新 陶大勇 张江铃 白占明 |
| 作者单位： | 1. 西北农林科技大学动物科技学院,陕西杨陵,712100 2. 西北农林科技大学动物科技学院,陕西杨陵,712100;河南科技大学动物科技学院,河南洛阳,471003 3. 西北农林科技大学动物科技学院,陕西杨陵,712100;西藏农牧科学院畜牧兽医研究所,西藏拉萨,850000 4. 西北农林科技大学动物科技学院,陕西杨陵,712100;塔里木大学动物科技学院,新疆阿拉尔,843300 |
| 摘 要： | 分析了SMM在健康家兔及肾损害兔体内的药物动力学过程。12只家兔分为A、B两组。A组为健康对照组,B组为肾功能损害病理模型组。A、B两组家兔均以140 mg/kg(SMM)剂量耳静脉注射SMM-Na,给药前心脏采血0.5 mL,作为空白对照。分别于给药后0.08、0.25、0.5、1、2、3、4、6 h各采血0.5 mL。以Annino法分析游离SMM血药浓度。结果显示,SMM在家兔体内药物动力学配置符合二室开放模型。药时曲线最佳方程为:C正常=13.910e-6.830t 32.569e-1.076t,C肾损害=15.748e-4.542t 27.473e-0.323t。肾损害时药动学参数与健康时的比较,α下降了33.49%;β下降了69.98%;t1/2α增加了41.03%;t1/2β增加了237.5%;AUC增加了33.49%;CLB下降了69.98%。表明家兔肾功能损害后,SMM在其体内消除显著变慢。提示在肾脏损害时应相应增大SMM给药间隔时间或减小给药剂量。 |
| 关 键 词： | 磺胺间甲氧嘧啶(SMM) 肾功能损害 家兔 药物动力学 |
| 文章编号： | 1004-1389（2006）05-0006-04 |
| 收稿时间： | 2005-12-30 |
| 修稿时间： | 2006-04-10 |
The Pharmacokinetics of Sulfamonomethoxinum in Rabbits with Experimental Reduced Renal Functions |
|
| LI Yin-qian,HAO Cai-ju,LIU Xiao-qiang,BAI Dong-ying,SHE Yong-xin,TAO Da-yong,ZHANG Jiang-ling and BAI Zhan-ming.The Pharmacokinetics of Sulfamonomethoxinum in Rabbits with Experimental Reduced Renal Functions[J].Acta Agriculturae Boreali-occidentalis Sinica,2006,15(5):6-9. | |
| Authors: | LI Yin-qian HAO Cai-ju LIU Xiao-qiang BAI Dong-ying SHE Yong-xin TAO Da-yong ZHANG Jiang-ling and BAI Zhan-ming |
| Institution: | College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471003, China;College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi 712100, China;Institute of Animal Science and Veterinary Medicine, Tibet Academy of Agricultrual and Animal Husbandry Science, Lasa Tibet 850000, China;College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Tarim University, Alar Xinjiang 843300, China;College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi 712100, China;College of Animal Science and Technology, Northwest A & F University, Yangling Shaanxi 712100, China |
| Abstract: | |
| Keywords: | Sulfamonomethoxinum(SMM) Experimental reduced renal functions Rabbits Pharmacokinetics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《西北农业学报》浏览原始摘要信息 | |
| 点击此处可从《西北农业学报》下载免费的PDF全文 | |