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Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc |
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| Authors: | Khan Inamullah Nisar Muhammad Shah Muhammad Raza Shah Hamidullah Gilani Syed Naeemuddin Gul Farah Abdullah Syed Muhammad Ismail Mohammad Khan Nematullah Kaleem Waqar Ahmad Qayum Mughal Khan Haroon Obaidullah Samiullah Ullah Majeed |
| Institution: | aDepartment of Pharmacy, University of Peshawar, 25120, Pakistan;bInstitute of Chemical Sciences, University of Peshawar, 25120, Pakistan;cHEJ Research Institute, ICCBS, Karachi University, 75270, Pakistan;dDepartment of Agricultural Chemistry, Agricultural University, Peshawar, Pakistan;ePharmacology section, PCSIR Lab Complex, Peshawar, 25000, Pakistan;fDepartment of Computer Science, Islamia College University, Peshawar 25120, Pakistan |
| Abstract: | Current study was conducted to identify constituents of Taxus wallichiana Zucc. that might be responsible for its folk use in anti-inflammatory conditions. Taxusabietane A was isolated from the bark extract of Taxus wallichiana Zucc. Taxusabietane A was analyzed for in-vitro and in-vivo anti-inflammatory activities using Lipoxygenase (LOX) inhibition assay and carrageenan-induced paw edema model. Taxusabietane A revealed considerable LOX inhibitory activity with the IC50 value being 57 ± 0.31. Standard compound Baicalein showed the IC50 value being 22.1 ± 0.03 μM. Taxusabietane A also showed significant (5 and 10 mg/kg) anti-inflammatory activity induced by carrageenan. However, this study highlighted the potential of Taxusabietane A to be further explored as a new lead compound for management of conditions associated with inflammation. |
| Keywords: | Lipoxygenase Carrageenan Anti-inflammatory |
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