Passive protection of dogs against clinical disease due to Canine parvovirus-2 by specific antibody from chicken egg yolk |
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| Authors: | Sa Van Nguyen Kouji Umeda Hideaki Yokoyama Yukinobu Tohya and Yoshikatsu Kodama |
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| Institution: | Immunology Research Institute, GHEN Corporation, 839-1 Sano, Gifu City, 501-1101, Japan. nguyen@ghen.co.jp |
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| Abstract: | The protective effect of immunoglobulins derived from chicken egg yolk (IgY) against infection by Canine parvovirus 2 (CPV-2) was evaluated in 10 beagle dogs orally challenged with a strain of the virus. The 2-mo-old dogs were divided into 3 groups and treated with powders containing CPV-2 IgY or normal egg yolk for 7 d after the challenge. The 4 dogs receiving normal egg yolk (control group) demonstrated mild symptoms typical of CPV-2 infection, such as vomiting, diarrhea, and weight loss. No symptoms were observed by 16 d after challenge in the 3 dogs receiving 2 g of IgY powder. Of the 3 dogs receiving 0.5 g of IgY powder, 2 had clinical CPV-2 disease; however, the manifestations were less severe than in the control group. Furthermore, the IgY-treated groups had significantly greater weight gain and shorter duration of virus shedding than the control group. These results indicate that IgY is useful in protecting dogs from CPV-2-induced clinical disease. |
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