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| 动物机体热休克应答相关信号途径的研究进展 | |
| 引用本文： | 刘吉茹,张勇,顾宪红.动物机体热休克应答相关信号途径的研究进展[J].家畜生态学报,2013,34(7):1-5. |
| 作者姓名： | 刘吉茹 张勇 顾宪红 |
| 作者单位： | 1.中国农业科学院 北京畜牧兽医研究所，动物营养学国家重点实验室，北京 100193； 2.沈阳农业大学 畜牧兽医学院，辽宁 沈阳 110866 |
| 基金项目： | 国家重点基础研究发展计划课题(2012CB124706)；国家科技支撑计划课题(2012BAD39B02)资助 |
| 摘 要： | 动物处于不良饲养、运输、屠宰等环境下产生热应激,机体对热应激的反应称为热休克应答,多条信号途径调控热休克应答,引发热休克蛋白的产生。本文综述了MAPK、PI3K/Akt、PKC等信号途径对热休克蛋白的调控作用,从分子机制上阐明了热应激的调控机理。 |
| 关 键 词： | 热应激 热休克应答 热休克蛋白 信号途径 |
A Review on of Signaling Pathways Related to Heat Shock Response in Animal Body |
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| LIU Ji-ru,ZHANG Yong,GU Xian-hong.A Review on of Signaling Pathways Related to Heat Shock Response in Animal Body[J].Acta Ecologae Animalis Domastici,2013,34(7):1-5. | |
| Authors: | LIU Ji-ru ZHANG Yong GU Xian-hong |
| Institution: | 1.State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agriculture Science, Beijing 110193,China; 2. College of Veterinary and Animal Science, Shenyang Agricultural University, Shenyang,Liaoning 110866, China |
| Abstract: | Heat stress happened when animals were fed, transported and slaughtered in poor conditions, the body's response to heat stress was called heat shock response. Multiple signaling pathways regulated heat shock response with the result of producing heat shock proteins. The paper reviewed the mechanisms of MAPK, PI3K/Akt and PKC signaling pathways regulating heat shock protein, clarified the mechanism of heat stress at molecular level. |
| Keywords: | heat stress heat shock response heat shock protein signaling pathway |
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