Structural and functional changes of neuronal and glial components of the feline enteric nervous system in cats with chronic inflammatory and non-inflammatory diseases of the gastrointestinal tract |
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| Institution: | 1. Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany;2. Small Animal Clinic, University of Veterinary Medicine Hannover, Bünteweg 9, D-30559 Hannover, Germany;1. Palacky University of Olomouc, Department of Geology, 17. listopadu 12, 771 46 Olomouc, Czech Republic;2. CEITEC IPM, Institute of Physics of Materials, v.v.i., Academy of Sciences of the Czech Republic, Zizkova 22, 616 62 Brno, Czech Republic;1. Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, Maryland;2. Division of Diagnostic Imaging, Department of Radiology, The Johns Hopkins Hospital, Baltimore, Maryland;1. Parasitology Laboratory, National Medicine Veterinary School, 2020 Sidi Thabet, Tunisia;2. Ecosystems and Environment Research Centre, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK;3. Tunis Abattoir, Health Hygiene and Environment Service, Ministry of Interieur, Tunis, Tunisia;4. Section of Epidemiology, Vetsuisse Faculty, Winterthurestrasse 270, 8057 Zurich, Switzerland;1. Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, An denTierkliniken 33, 04103 Leipzig, Germany;2. The Royal Veterinary College, Department of Pathology and Pathogen Biology, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK;3. Department of Neuropathology, University Medical Center Göttingen, Georg-August University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany;4. Paul-Flechsig-Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany;6. Tierarztpraxis Dr. J. Mollidor, Niehler Str. 68, 50733 Köln, Germany;1. Laboratory of Genomics, Department of Animal Genomics and Molecular Biology, National Research Institute of Animal Production, Krakowska 1, 32-083, Balice, Poland;2. Swiss Institute of Equine Medicine ISME, Faculty of Veterinary Medicine, University of Bern and Agroscope, Länggassstrasse 124c, Postfach 8466, CH-3001, Bern, Switzerland;3. Equine Clinic: Surgery and Radiology, Department of Veterinary Medicine, Free University of Berlin, Oertzenweg 19b, 14163, Berlin, Germany;4. Department of Animal Reproduction, Institute of Veterinary Medicine, University of Agriculture, Al. Mickiewicza 21, 31-120, Krakow, Poland |
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| Abstract: | Immunohistochemical examinations of the enteric nervous system (ENS) were performed on biopsies of healthy cats and compared to findings in cats suffering from inflammatory bowel disease or intestinal lymphoma. In lymphocytic–plasmacytic enterocolitis all affected samples had significant reductions in glial fibrillary acidic protein and vasoactive intestinal peptide (VIP) and mostly of neuron-specific enolase (NSE) possibly reflecting alterations in enteric glial cells and neurons. In cases with eosinophilic gastroenterocolitis significantly reduced phosphorylated neurofilament (PN) expression was present suggesting a disturbance in neuronal cytoskeleton, whereas cats with fibrosing enteropathy had reduced expression of NSE, non-phosphorylated neurofilaments (NPN), PN and VIP, possibly reflecting neuronal disturbances. In cases with intestinal lymphoma only the reduction in PN and the increase in NPN were obvious suggesting direct damage or interference of neoplastic cells with enteric neurons. In conclusion, structural and functional alterations of the ENS may contribute to clinically evident signs of vomiting and/or diarrhea. |
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