| 伊维菌素吡喹酮咀嚼片溶出度方法的建立 |
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| 引用本文： | 杨 星,马秋冉,董玲玲,赵富华,于晓辉.伊维菌素吡喹酮咀嚼片溶出度方法的建立[J].中国兽药杂志,2019,53(12):17-22. |
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| 作者姓名： | 杨 星 马秋冉 董玲玲 赵富华 于晓辉 |
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| 作者单位： | 中国兽医药品监察所,,,,中国兽医药品监察所 |
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| 基金项目： | “十二五”科技支撑计划（2015BAD11B03-4） |
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| 摘 要： | 为了建立同时测定伊维菌素吡喹酮咀嚼片两种主药溶出度的测定方法,采用高效液相色谱法测定在不同pH值溶出介质、不同浓度表面活性剂和不同转速的条件下伊维菌素吡喹酮咀嚼片两种主药的溶出曲线,确定了伊维菌素吡喹酮咀嚼片的溶出方法。结果显示,三批样品45 min时伊维菌素、吡喹酮两种主药的溶出度均大于85%。建立的溶出度测定方法可用于伊维菌素吡喹酮咀嚼片溶出度的测定。
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| 关 键 词： | 伊维菌素吡喹酮咀嚼片 溶出度 高效液相色谱法 |
| 收稿时间： | 2019/8/6 0:00:00 |
| 修稿时间： | 2019/8/19 0:00:00 |
Establishment of dissolution test method of Ivermectin and Praziquantel Chewable Tablets |
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| Institution: | China Institute of Veterinary Drug Control,Beijing,100081;China,,,, |
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| Abstract: | The article established a method to simultaneously determine the dissolution of two main ingredients of ivermectin and praziquantel chewable tablets. The method was determined by the dissolution curves of ivermectin and praziquantel which were tested by high performance liquid chromatography method in different kinds of dissolution mediums at different rotation speeds. The dissolution of ivermectin and praziquantel in three batches of samples were above 85% at 45 minute. This method can be used for determining the dissolution of ivermectin and praziquantel chewable tablets. |
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| Keywords: | ivermectin and praziquantel chewable tablets dissolution HPLC |
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