Protective effect of A. auricula-judae extracts on liver function in septic rats |
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| Authors: | SUN Zhan MA Xiao-juan YAO Xue-ping YU Wen-yan MA Qi |
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| Institution: | 1.Laboratory of Functional Science;2.Department of Pathophysiology, Basic Medical College, Xinjiang Medical University, Urumqi 830054, China. |
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| Abstract: | AIM: To explore the effects of Auricularia (A.) auricula-judae extracts on the liver function in septic rats. METHODS: Forty male Wistar rats were randomly divided into control group, model group, A. auricula-judae polysaccharide group and A. auricula-judae crude extract group. Septic model was induced by the procedure of cecal ligation and puncture (CLP). Intragastric administration was performed every 8 h 3 days prior to CLP. The plasma levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), endotoxin(ET), tumor necrosis factor α(TNF-α), interleukin 6(IL-6) and IL-1β were detected 12 h after CLP. The specimens of the liver were collected to observe the pathological changes. The expression of NF-κB in the liver tissues was detected by the method of immunohistochemistry. RESULTS: Compared with the CLP rats, the intervention of A. auricula-judae polysaccharide and A. auricula-judae crude extract to the septic rats significantly decreased the serum levels of ALT, AST, ET, TNF-α, IL-1β and IL-6 (P<005). The pathological changes of the liver tissues in treatment groups were significantly attenuated compared with CLP group. CONCLUSION: A. auricula-judae polysaccharide and A. auricula-judae crude extract protect liver against sepsis-induced injury by inhibiting the systemic inflammatory response. |
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| Keywords: | Auricularia auricula-judae extract Sepsis Liver function Systemic inflammatory response syndrome |
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