| 生长激素激活受体机理的研究进展 |
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| 引用本文： | 杨艳红,付志玲,兰海楠,李维,刘禹,郭风,张辉,崔焕忠,赵雪,郑鑫.生长激素激活受体机理的研究进展[J].中国畜牧兽医,2013,40(10):148-151. |
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| 作者姓名： | 杨艳红 付志玲 兰海楠 李维 刘禹 郭风 张辉 崔焕忠 赵雪 郑鑫 |
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| 作者单位： | 吉林农业大学动物科技学院, 吉林长春 130118 |
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| 基金项目： | 国家自然科学基金(30871842);吉林省教育厅十二五技术研究项目(201239)。 |
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| 摘 要： | 生长激素(growth hormone,GH)是一种含有191个氨基酸的多肽类激素,分子质量为22 ku,由垂体前叶分泌进入血液循环,与靶细胞膜表面以二聚体形式存在的生长激素受体(growth hormone receptor,GHR)相结合。对于受体的激活来说,仅是二聚化还不够,还需在GH的诱导下发生构象变化,进而才能诱发Janus激酶2(Janus kinase 2,JAK2)的酪氨酸磷酸化,并通过4条不同的路径将信号传入细胞内,从而发挥代谢、增殖及分化等一系列生理效应。作者就生长激素与受体的结构、作用机理、信号转导通路的进展进行综述。
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| 关 键 词： | 生长激素 生长激素受体 作用机理 信号转导 |
| 收稿时间： | 2013-02-02 |
Research Progress on the Mechanism of Growth Hormone-activated Receptor |
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| YANG Yan-hong,FU Zhi-ling,LAN Hai-nan,LI Wei,LIU Yu,GUO Feng,ZHANG Hui,CUI Huan-zhong,ZHAO Xue,ZHENG Xin.Research Progress on the Mechanism of Growth Hormone-activated Receptor[J].China Animal Husbandry & Veterinary Medicine,2013,40(10):148-151. |
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| Authors: | YANG Yan-hong FU Zhi-ling LAN Hai-nan LI Wei LIU Yu GUO Feng ZHANG Hui CUI Huan-zhong ZHAO Xue ZHENG Xin |
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| Institution: | College of Animal Science, Jilin Agricultural University, Changchun 130118, China |
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| Abstract: | The growth hormone (GH),a 191 amino acid polypeptide secreted by the anterior pituitary into the blood circulation,has a molecular weight of 22 ku. It binds to membrane receptors existing as a preformed dimer in target tissues to cause a conformational change to exert on its effects. Janus kinase 2 (JAK2) and other cytokines are rapidly activated after GH binding and induced four different signal transduction pathways which bring signal into cells to generate a series of physiological effects such as metabolism,proliferation and differentiation. This article reviewed the structure,mechanism of action,and signal transduction pathways of growth hormone and growth hormone receptor. |
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| Keywords: | growth hormone growth hormone receptor mechanism of action signal transduction |
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