Evaluation of the toxicity of Adonis aestivalis in sheep |
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| Authors: | Woods L W Puschner B Filigenzi M S Woods D M George L W |
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| Institution: | California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, PO Box 1770, Davis, CA 95617, USA. lwwoods@ucdavis.edu |
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| Abstract: | To determine the toxicity of Adonis aestivalis (adonis) in sheep, adult Suffolk ewes were administered 1 per cent bodyweight adonis via surgically placed rumen cannulas in an acute, high-dose toxicity study, and 0.2 per cent bodyweight daily in a two-week, low-dose toxicity study. The ewes received cardiac examinations before dosing, 24 and 48 hours after dosing with 1 per cent bodyweight adonis, and after continuous low-dose administration. All the ewes administered adonis had transient sinus arrhythmias after receiving 1 per cent bodyweight adonis. Two of the three ewes had transient reduced fractional shortening after administration with 1 per cent bodyweight adonis; the same two ewes had reduced fractional shortening after the low-dose treatment regimen. No gross or microscopic lesions were seen when the ewes were examined postmortem at the end of the study. |
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