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| 铜绿假单胞菌生物膜研究进展 | |
| 引用本文： | 孟菲,黎书长,杨武宁,刘伟,银慧慧,韦晓洁,姜源明,赵武,覃振华,孙建华.铜绿假单胞菌生物膜研究进展[J].中国畜牧兽医,2016,43(11):2976-2981. |
| 作者姓名： | 孟菲 黎书长 杨武宁 刘伟 银慧慧 韦晓洁 姜源明 赵武 覃振华 孙建华 |
| 作者单位： | 1. 广西壮族自治区兽医研究所, 广西动物疫病病原生物学与诊断重点实验室, 南宁 530001; 2. 广西大学动物科学技术学院, 南宁 530004; 3. 广西壮族自治区兽药监察所, 南宁 530001 |
| 基金项目： | 广西基本科研业务费专项项目（14-5） |
| 摘 要： | 条件致病菌铜绿假单胞菌（PA）是一种能形成生物膜的革兰氏阴性菌，作者综述了PA生物膜形成的生物学机制，包括菌体黏附、胞外多糖Psl和Pel、藻朊酸盐等参与细菌生物膜成熟的过程及群体感应系统调节相关因子表达，从而调控细菌形成生物膜应对不良环境。此外还概括了将生物膜作为靶点开发的药物等生物膜相关的研究进展。生物膜是菌体逃避有害刺激的护盾，研究其结构、形成及致病机理，了解PA产生耐药性的分子机制，对于通过调节生物膜形成或调控生物膜相关因子的表达进而优化PA的抗感染治疗有十分重要的意义。 |
| 关 键 词： | 铜绿假单胞菌 生物膜 群体感应系统 |
| 收稿时间： | 2016-03-12 |
Research Progress on Biofilms in Pseudomonas aeruginosa |
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| MENG Fei,LI Shu-chang,YANG Wu-ning,LIU Wei,YIN Hui-hui,WEI Xiao-jie,JIANG Yuan-ming,ZHAO Wu,QIN Zhen-hua,SUN Jian-hua.Research Progress on Biofilms in Pseudomonas aeruginosa[J].China Animal Husbandry & Veterinary Medicine,2016,43(11):2976-2981. | |
| Authors: | MENG Fei LI Shu-chang YANG Wu-ning LIU Wei YIN Hui-hui WEI Xiao-jie JIANG Yuan-ming ZHAO Wu QIN Zhen-hua SUN Jian-hua |
| Institution: | 1. Guangxi Key Laboratory of Animal Epidemic Etiology and Diagnostic, Guangxi Veterinary Research Institute, Nanning 530001, China; 2. College of Animal Science and Technology, Guangxi University, Nanning 530004, China; 3. Institute of Veterinary Drug Control of Guangxi Zhuang Autonomous Region, Nanning 530001, China |
| Abstract: | The opportunistic pathogen Pseudomonas aeruginosa is a gram-negative bacteria which can form biofilms.In this review,we summarized the biology mechanism of biofilms in Pseudomonas aeruginosa,including Pseudomonas aeruginosa adhesion,extracellular polysaccharide Psl and Pel,alginate participated in the biofilm maturation,and quorum sensing systems regulated the formation of biofilm in Pseudomonas aeruginosa,and the drug target on biofilm.The bacterial biofilms protected the bacteria from unsuitable environmental conditions.Through researching the structure and the pathogenesis of Pseudomonas aeruginosa,and its resistance molecular mechanisms,we could adjust or regulate the expression of biofilm-associated factors,optimize the anti-infection treatment in Pseudomonas aeruginosa. |
| Keywords: | Pseudomonas aeruginosa biofilms quoring sensing system |
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