Pivotal role of microRNAs in cardiac development and heart diseases |
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| Authors: | WEI Cong HU Bing SHEN E |
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| Institution: | Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth Peoples Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, China. E-mail: shene1001@hotmail.com |
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| Abstract: | MicroRNAs (miRNAs) are non-coding small RNAs, which bind to the 3'-UTR of target mRNAs and negatively regulate the gene expression. Accumulating evidence demonstrates that miRNAs are involved in many biological processes such as embryo development, cell proliferation, differentiation, apoptosis and tumorigenesis. Heart development and heart diseases are complex processes controlled by various signaling pathways. Recent researches indicate the importance of miRNAs in the process of cardiac development and heart diseases. In this review, the role of miRNAs in cardiac development and the pathogenesis of heart diseases are overviewed. The insight into the regulating miRNAs will significantly expand the cardiovascular therapeutic strategies beyond classical pharmacology. |
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| Keywords: | MicroRNA Heart development Hypertrophy Arrhythmia |
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