Modulation of K+ channels by Ca2+ and pH in regulatory volume decrease |
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| Authors: | YANG Lin-jie WANG Li-wei CHEN Li-xin |
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| Institution: | 1. Department of Pharmacology, Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China;
2. Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China |
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| Abstract: | It has been widely appreciated that animal cells rely on the mechanism of regulatory volume decrease(RVD) after swell in a hypotonic environment. Activation of K channels is crucial in the process of self-protection. There are a characterized increase in cytoplasmic Ca and a decrease in pH in the process of RVD in many cell types. Ca entry via transient receptor potential(TRP) channel is crucial for the cytoplasmic Ca increase, which in turn induces the decrease in pH.The increase in cytoplasmic Ca and decrease in pH activate or inhibit the activity of K channel, respectively. In this review, the regulatory network at cellular level between cytoplasmic Ca and pH, and the modulation of K channels by Ca and pH in the process of RVD are discussed. |
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| Keywords: | Regulatory volume decrease Calcium Transient receptor potential channels pH K channels |
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