| 不同给药方式下培氟沙星在鲤体内的药代动力学研究 |
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| 引用本文： | 李改娟,刘艳辉,祖岫杰,鞠松柏,王文兰,陈伟强,刘铁钢.不同给药方式下培氟沙星在鲤体内的药代动力学研究[J].大连海洋大学学报,2014(4):386-390. |
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| 作者姓名： | 李改娟 刘艳辉 祖岫杰 鞠松柏 王文兰 陈伟强 刘铁钢 |
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| 作者单位： | 吉林省水产科学研究院,吉林长春130033 |
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| 基金项目： | 国家现代农业产业技术体系（CARS-46-29）;吉林省公益性科研院所行业科研项目;吉林省世行贷款农产品质量安全项目（2011-YS9）;吉林省科技发展计划项目（20140417021CB） |
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| 摘 要： | 在水温为18℃下,按10 mg/kg（体质量）对体质量为（200±30）g的福瑞鲤Cyprinus carpio单次肌肉注射和混饲口灌培氟沙星,于不同时间点采集鲤血浆、肌肉、肝胰脏、肾脏组织,经超高液相色谱法测定各组织中培氟沙星的浓度,并采用DAS 3.0药物代谢动力学软件的非房室模型统计矩方法分析药时数据。结果表明：混饲口灌给药和肌注给药后,培氟沙星的药时曲线下面积（ AUC）分别为88.35、139.9 mg·h/L,达峰浓度（ Cmax ）分别为2.092、3.687 mg/L,达峰时间（ Tmax ）分别为4.0、0.5 h,消除半衰期（ t1/2）分别为22.301、74.357 h,表观分布容积（ Vd ）分别为5.464、15.342 L/kg,总体清除率（ CL ）分别为0.170、0.143 L·kg/h。研究表明,肌肉注射给药较混饲口灌达峰时间短,达峰浓度高,半衰期长,生物利用度高。
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| 关 键 词： | 鲤 培氟沙星 药代动力学 给药方案 |
Pharmacokinetics of pefloxacin in common carp challenged by a single intramuscular injection and oral administration |
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| Authors: | LI Gai-juan LIU Yan-hui ZU Xiu-jie JU Song-bai WANG Wen-lan CHEN Wei-qiang LIU Tie-gang |
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| Institution: | (Jilin Fisheries Research Institute, Changehun 130033, China) |
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| Abstract: | The concentration of pefloxacin was determined in plasma, muscle, hepatopancreas and kidney of FFRC common carp Cyprinus carpio strain with body weight of （200±30）g challenged by a single intramuscular injection and oral administration at a dose of 10 mg/kg body weight by the ultrahigh performance liquid chromatography at water temperature of 18 ℃, and the data were analyzed by the non-compartmental analysis method of DAS 3 . 0 pharmacokinetic program software to establish a reasonable withdrawal period for pefloxacin in common carp. The Auc was found to be 88. 35 mg·h/L for oral administration and 139. 9 mg·h/L for the injection. The elimination half-life（t1/2） was found to be 22. 301 h after oral administration and 74. 357 h after injection,and the volume of distribution（Vd） 5. 464 L/kg for oral administration and 15. 342 L/kg for the injection. The peak concentration of the pefloxacin （Cmax） was 2. 092 mg/L for oral administration and 3. 687 mg/L for the injection, and the peak time （Tmax） 4. 0 h for oral administration and 0. 5 h for the injection. The total body clearance（CL） of pefloxacin was 0. 170 L·kg/h for oral administration and 0. 143 L·kg/h for the injection. It is concluded that more quickly ab-sorption, higher peak plasma concentration, higher bioavailability and faster elimination is observed in intramuscu-lar injection compared with the oral administration. |
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| Keywords: | common carp pefloxacin pharmacokinetics dosage regime |
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