Cluster Analysis of Differentially Expressed Heat Stress Genes in Rat Jejunal Mucosal |
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| Authors: | Hong ZHAO ;Huichuan WANG ;Dan JIA ;Tingyu YAN ;Fenghua LIU |
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| Institution: | [1]Department of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China; [2]Department of Basic Courses, Beijing University of Agriculture, Beijing 102206, China |
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| Abstract: | Objective] The aim was to study the heat stress mechanism of differentially expressed genes in rat jejunal mucosal. Method] Variable cluster analysis and cluster analysis of samples on the differentially expressed heat stress genes in rat jejunal mucosal were carried out with SAS software, and statistics of distribution of the differentially expressed genes on chromosomes were conducted. Result] The differentially expressed genes were divided into seven categories, of which, the upregulated genes included three categories(i.e.: Category A: Hspa1 a, Hspa1 b,Hspb1, Hsph1, Dnaja4, Ahsa2 and P4ha1; Category B: Cyp1a2, Zbtb16, Gucy2 g,Fgb, Cyp4a3 and Etv2; and Category C: Cyp1a2, Chac1 and Cyp4b1) and the down-regulated genes included four categories(i.e.: Category D: Tlr2, Noxo1,LOC286989 and Aspg; Category E: RGD1560395, Alb and BQ194726; Category F:Ccl4, Gzmk, AI228153, Anxa10, S100a9 and Ascl5; and Category G: Reg1 a and Slc13a1). The classification, function and reasons of differential expression for each gene category were analyzed. Conclusion] Most of the three categories of up-regulated genes were related to the heat shock proteins; and most of the four categories of down-regulated genes were related to the immunity, providing reference for discussion of the heat stress mechanism. |
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| Keywords: | Rat Heat stress Jejunal mucosal DNA microarray Cluster analysis SAS software |
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