| 重组禽流感病毒灭活疫苗(H5N1亚型,Re-1株)免疫鸡抗体消长规律及免疫程序的初步研究 |
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| 引用本文： | 周锦萍,刘佩红,倪卫忠,潘水春,徐新红,奚志龙,严鸣敏.重组禽流感病毒灭活疫苗(H5N1亚型,Re-1株)免疫鸡抗体消长规律及免疫程序的初步研究[J].中国兽药杂志,2007,41(3):5-9. |
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| 作者姓名： | 周锦萍 刘佩红 倪卫忠 潘水春 徐新红 奚志龙 严鸣敏 |
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| 作者单位： | 1. 上海市畜牧兽医站,上海,201103
2. 上海市南汇区动物疫病预防控制中心,上海,201800 |
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| 摘 要： | 研究新型重组H5N1亚型禽流感灭活疫苗对种鸡和肉鸡的免疫原性,并对雏鸡母源抗体和免疫后的抗体进行动态观察,根据试验结果推荐该疫苗对鸡的免疫程序。用HI方法检测种鸡、肉鸡的母源抗体和免疫抗体,根据母源抗体的衰减和免疫抗体的消长规律确定首免和再免日龄。结果表明种鸡的母源抗体约能维持10 d多;0.3 mL/羽首免后10 d HI抗体就可达到6.40 log2,3-5周达到高峰期,至免疫17周后(19周龄)HI抗体水平仍然维持在4.88 log2;19周龄时0.5 mL/羽进行二免,有效抗体能维持约20周;280日龄0.5 mL/羽三免后抗体水平均一,下降缓慢,至种鸡淘汰时(三免后29周)抗体水平仍能维持在5.32 log2。肉鸡母源抗体约能维持7d,10日龄时0.3 mL/羽免疫,有效抗体能维持到上市。新型重组H5N1亚型禽流感灭活疫苗对鸡的免疫原性确实。
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| 关 键 词： | 禽流感 重组疫苗 H5N1亚型 抗体消长规律 免疫程序 |
| 文章编号： | 1002-1280（2007）03-0005-05 |
| 修稿时间： | 2006-08-30 |
Study on the Eating and Flowing Laws of Antibody Induced by Recombinant Avian Influenza Inactivated Vaccine (H5N1 Subtype) and Preliminary Study on Immune Procedure |
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| ZHOU Jin-ping,LIU Pei-hong,NI Wei-zhong,PAN Shui-chun,XU Xin-hong,XI Zhi-long,YAN Ming-min.Study on the Eating and Flowing Laws of Antibody Induced by Recombinant Avian Influenza Inactivated Vaccine (H5N1 Subtype) and Preliminary Study on Immune Procedure[J].Chinese Journal of Veterinary Drug,2007,41(3):5-9. |
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| Authors: | ZHOU Jin-ping LIU Pei-hong NI Wei-zhong PAN Shui-chun XU Xin-hong XI Zhi-long YAN Ming-min |
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| Institution: | 1. Shanghai Municipal Animal Husbandry and Veterinary Station , Shanghai, 201103 ; 2. Shanghai Nanhui District Animal Diseases Control and Prevention Centre, Shanghai, 201800; China |
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| Abstract: | Serum antibodies in chickens were detected by HI test,that were induced by recombinant highly pathogenic avian influenza(HPAI) inactivated vaccine(H5N1 Subtype),and the eating and flowing laws of the vaccine-induced antibodies and the vaccine dosage was also examined.The maternal antibody could last 10 days in breeding chickens.The HI antibody was 6.40log2,and the peak value appeared in week 3 to 5.The HI antibody could maintain 4.88log2 in week 19.Then the second immune injection adopted 0.5 mL/bird,the effective antibody could last 20 weeks.The third immune injection of 0.5 mL/bird on day 280,the antibody level was steady 5.32log2 till the bird being culled out.The maternal antibody could last 8 days in broiler chickens.The dose of neck hypodermic immune was 0.3 mL/bird on day 10,the antibody was effective even when chickens be carried into market.So the recombinant AI inactivated vaccine(H5N1 Subtype) was effective in preventing AIV challenge for chickens. |
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| Keywords: | AIV recombinant inactivated vaccine H5N1 the eating and flowing laws immune procedure |
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