| Cu2+对蚯蚓和家兔AChE毒性研究 |
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| 引用本文： | 张轶辉,崔小伟,毕亚玲,王波.Cu2+对蚯蚓和家兔AChE毒性研究[J].安徽农业科学,2011,39(25):15342-15344. |
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| 作者姓名： | 张轶辉 崔小伟 毕亚玲 王波 |
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| 作者单位： | 安徽科技学院植物科学学院,安徽凤阳,233100;河南省农业科学院植物保护研究所,河南郑州,450002 |
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| 基金项目： | 安徽科技学院引进人才项目 |
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| 摘 要： | 采用体外试验方法,以蚯蚓和家兔为研究对象,分别测定了Cu2＋对二者AChE的半抑制浓度（IC50）和双分子速率Ki。结果表明,在抑制时间为10 min时Cu2＋对蚯蚓AChE和家兔脑部AChE的IC50分别为3.6和2.4 mmol/L;在IC50浓度的Cu2＋作用下,Cu2＋对家兔脑部AChE的Ki值较大,为Cu2＋对蚯蚓AChE的3.59倍,表明家兔脑部AChE较蚯蚓AchE对Cu2＋更为敏感。
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| 关 键 词： | AChE Cu2 毒性 |
Study on Toxic Effect of Cu2 + on Acetylcholinesterases (ACHE) of Two Living Things |
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| Institution: | ZHANG Yi-hui et al(College of Plant Sciences,Anhui Science and Technology University,Fengyang,Anhui 233100) |
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| Abstract: | Effects of Cu2+ on acetylcholinesterase(AChE) of habit brain and earthworm was evaluated in vitro.Results showed that AChE activities were depressed significantly by concentration ranges of Cu2+ respectively.The IC50 values of Cu2+ were 3.6 and 2.4 mmol/L,respectively.Under the function of Cu2+ with IC50 concentration,Ki value of AChE from habit brain was 3.59 times of that of earthworm,this show that AChE from habit brain had higher sensitivity to Cu2+ than that of earthworm. |
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| Keywords: | AChE Cu2+ Toxicity |
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