Pharmacokinetics of total thyroxine in dogs after administration of an oral solution of levothyroxine sodium |
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| Authors: | Le Traon G Burgaud S Horspool L J I |
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| Institution: | Intervet Pharma R&D, a part of Schering-Plough Corporation, Beaucouzé, France;;Intervet International bv, a part of Schering-Plough Corporation, Boxmeer, The Netherlands |
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| Abstract: | Oral l -thyroxine ( l -T4) supplementation is used to replace thyroid hormone concentrations in dogs with hypothyroidism. The pharmacokinetics of l -T4 following administration of a solution (Leventa®) was investigated in healthy dogs. l -T4 was absorbed fairly rapidly ( t max 3 h). A mean bioavailability of 22% was calculated following a single oral administration of 40 μg l -T4/kg body weight. Repeated oral administration at the same dose for 14 consecutive days did not lead to any accumulation of T4 in serum. After intravenous administration of l -T4, a serum half-life of 11.6 h was calculated. Food intake concomitant with l -T4 oral administration delayed l -T4 absorption and decreased its rate and extent by about 45%. The relative bioavailability of l -T4 following administration of a tablet formulation was about 50% of that of the l -T4 solution. The pharmacokinetic properties of liquid l -T4 after oral administration support the use of a dose rate of 20 μg/kg once daily, as a starting dose for replacement therapy in dogs with hypothyroidism. |
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