| 藻胆蛋白源生物活性肽研究进展 |
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| 引用本文： | 李富强,张廷新,李晓杰,朱丽萍,颜世敢.藻胆蛋白源生物活性肽研究进展[J].中国农学通报,2021,37(27):70-76. |
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| 作者姓名： | 李富强 张廷新 李晓杰 朱丽萍 颜世敢 |
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| 作者单位： | 齐鲁工业大学（山东省科学院）生物工程学院,山东省微生物工程重点实验室,济南 250353 |
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| 基金项目： | 山东省重点研发计划医用食品专项计划项目“特医食品中多肽组件高效精准检测技术和质量评价体系研究与应用”(2019YYSP024) |
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| 摘 要： | 本研究旨在为藻胆蛋白源生物活性肽的发掘、构-效关系表征提供重要参考,推动藻胆蛋白源生物活性肽的研发和应用。本研究综述了具有不同生物学活性的藻胆蛋白源活性肽,包括抗氧化肽、降血压肽、免疫调节肽、降糖肽、抗菌肽和抗炎肽等,归纳了藻胆蛋白源生物活性肽的来源、制备、结构鉴定、功能表征及构-效关系研究进展,指出利用传统方法研发生物活性肽存在一定盲目性,提出利用生物信息学与传统方法相结合有利于高效发掘新型藻胆蛋白源生物活性肽,为生物活性肽的研发提供了新策略。
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| 关 键 词： | 藻胆蛋白 生物活性肽 制备 功能 结构 构-效关系 |
| 收稿时间： | 2020-12-15 |
Bioactive Peptides Derived from Phycobiliprotein: A Review |
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| Li Fuqiang,Zhang Tingxin,Li Xiaojie,Zhu Liping,Yan Shigan.Bioactive Peptides Derived from Phycobiliprotein: A Review[J].Chinese Agricultural Science Bulletin,2021,37(27):70-76. |
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| Authors: | Li Fuqiang Zhang Tingxin Li Xiaojie Zhu Liping Yan Shigan |
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| Institution: | School of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Key Laboratory of Microbial Engineering of Shandong Province, Jinan 250353 |
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| Abstract: | The purpose of this study is to provide references for discovery and structure-activity relationship characterization of phycobiliprotein-derived bioactive peptides, and promote the development and application of phycobiliprotein-derived bioactive peptides. In this paper, phycobiliprotein-derived bioactive peptides with different biological activities, including antioxidant peptides, antihypertensive peptides, immunomodulatory peptides, hypoglycemic peptides, antibacterial peptides and anti-inflammatory peptides, were reviewed. The sources, preparation, structure, function, and structure-activity relationship of phycobiliprotein-derived bioactive peptides were summarized. Finally, it was pointed out that there was certain blindness in the research and development of bioactive peptides using traditional methods, however, the combination of bioinformatics and traditional methods was conducive to efficient exploring of novel bioactive peptides, and the study could provide a new approach for the development of phycobiliprotein-derived bioactive peptides. |
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| Keywords: | phycobiliprotein bioactive peptide preparation function structure structure-activity relationship |
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