| 氨甲喋呤(MTX)的直接碘标记方法研究 |
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| 引用本文： | 陆丽仪,黄永明,张京生.氨甲喋呤(MTX)的直接碘标记方法研究[J].核农学报,1989,3(3):175-178. |
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| 作者姓名： | 陆丽仪 黄永明 张京生 |
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| 作者单位： | 北京师范大学放化室,北京师范大学放化室,北京师范大学放化室 北京 ,北京 ,北京 |
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| 摘 要： | 本文报道了~125I(~131I)抗肿瘤药物氨甲喋呤的制备方法,用直接碘化法——NBS、ChT、Iodogen进行标记,并对这几种方法进行了比较。结果表明,NBS法最好,标记率达90—99％。经Sephadex G-75柱凝胶过滤后得到纯产品,放化纯度为95.4％。所制得的标记产品适用于示踪研究。
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| 关 键 词： | 氨甲喋呤 直接碘化法 N-溴代琥珀酰亚胺 氯胺T 1 3 4 6-四氯3α、6α-二苯甘脲 |
| 收稿时间： | 2009-12-31 |
| 修稿时间： | 2009-12-31 |
A STUDY OF DIRECT RADIOIODINATION METHOD FOR LABELLING ANTITUMOR DRUG-METHOTREXATE ( MTX ) |
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| Abstract: | The preparation of 125Ⅰ or131Ⅰ antitumor drug-methotrexate ( MTX ) with the aid of direct radioiodination method such as NBS, ChT and Iod-ogen ect, was described. Among the three methods compared, NBS is the best, its iodination efficiency is 90-99%. Purification of the product was carried out by Sephadex G-75 gel filtration column and the radiochemical purity is 95.4%.The labelled product is suitable for tracer studies. |
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| Keywords: | methotrexate ( MTX ) direct radioiodination method bromo-succinimide(NBS) chloramine T(chT) Iod-ogen |
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