Intraperitoneal antineoplastic drug delivery: experience with a cyclophosphamide,vincristine and prednisolone protocol in cats with malignant lymphoma |
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| Authors: | E Teske A J van Lankveld G R Rutteman |
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| Institution: | 1. Department of Clinical Sciences of Companion Animals, Veterinary Faculty, Utrecht University, , Utrecht, The 2. Netherlands |
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| Abstract: | In this retrospective study, the efficacy and safety were examined for an intraperitoneal chemotherapy protocol‐cyclophosphamide, vincristine and prednisolone (IP‐COP) in 26 cats with malignant lymphoma. Certainly in cats fiercely resisting IV administration the IP route is a more practical method, safer for the administrator and less stressful for the cat. Complete remission (CR) rate was 76.9% (n = 20). Median duration of first remission was 421 days. Estimated 1‐ and 2‐year disease free period were 67.1 and 48.0%, respectively. Median duration of survival was 388 days and estimated overall 1‐ and 2‐year survival periods were 54.7 and 46.9% respectively. Young cats had a more favourable prognosis. Reaching CR was essential for long‐term survival. No specific IP‐related adverse events (AE) were seen. AE were generally scored as mild and were not excessively abundant. These results indicate that the IP route is a safe and effective alternative for the administration of COP protocol chemotherapeutics. |
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| Keywords: | cat chemotherapy intraperitoneal lymphoma safety |
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