Toxicity and metabolism of methomyl in the European corn borer |
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| Authors: | RJ Kuhr CW Hessney |
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| Institution: | Department of Entomology, New York State Agricultural Experiment Station, Geneva, New York 14456 USA |
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| Abstract: | The contact and oral toxicity of methomyl (S-methyl N-(methylcarbamoyl)oxy] thioacetimidate) was similar for two different strains of European corn borer, Ostrinia nubilalis (Hübner). In each case, third- and fourth-instar larvae were equally susceptible, but fifth-instar insects were considerably more difficult to kill. In vivo and in vitro studies revealed that borers from both strains metabolized methomyl via a mixed-function oxidase system to water-soluble products which could not be cleaved by acid or hydrolytic enzymes. By far, the greatest metabolic activity was localized in fat body tissues of last-instar larvae, and although both strains metabolized methomyl at a similar rate, a large difference was found in the rate of metabolism of methomyl oxime. |
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