| 狐貉源犬瘟热病毒F蛋白基因的二级结构及其B细胞抗原表位预测 |
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| 引用本文： | 张立娜,王起,曾祥伟,贾竞波.狐貉源犬瘟热病毒F蛋白基因的二级结构及其B细胞抗原表位预测[J].经济动物学报,2010,14(2):80-83,86. |
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| 作者姓名： | 张立娜 王起 曾祥伟 贾竞波 |
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| 作者单位： | 1. 东北林业大学野生动物资源学院,哈尔滨,150040
2. 吉林省磐石市公安局,磐石,132300 |
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| 基金项目： | 教育部博士点青年教师基金，黑龙江省教育厅科学技术研究项目 |
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| 摘 要： | 以犬瘟热病毒基因组序列为材料,采用Garnier-Robson、Chou-Farsman和Karplus-Schultz方法预测了其结构蛋白的二级结构,用Kyte-Doolittle方法对结构蛋白的亲水性进行了分析,用Emini方法预测了结构蛋白的表面可及性,以Jameson-Wolf方法预测了蛋白的抗原指数,综合评价了犬瘟热病毒F蛋白的B细胞抗原表位。结果表明:F蛋白N端含有抗原指数较高的区域,提示可能含有潜在的B细胞优势抗原表位。
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| 关 键 词： | 犬瘟热病毒 结构蛋白 二级结构 B细胞抗原表位 |
Prediction of the Secondary Structure and B Cell Epitope for the Cap Protein of CDV |
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| ZHANG Li-na,WANG Qi,ZENG Xiang-wei,JIA Jing-bo.Prediction of the Secondary Structure and B Cell Epitope for the Cap Protein of CDV[J].Journal of Economic Animal,2010,14(2):80-83,86. |
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| Authors: | ZHANG Li-na WANG Qi ZENG Xiang-wei JIA Jing-bo |
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| Institution: | ZHANG Li-na1,WANG Qi2,ZENG Xiang-wei1,JIA Jing-bo1(1.College of Wildlife,Northeast Forestry University,Harbin 150040,China,2.Police Office of Panshi,Panshi 132300,China) |
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| Abstract: | To predict the secondary structure and B cell epitopes for cap protein of CDV,the secondary structure of cap protein was predicted by the methods of Garnier-Robson,Chou-Fasman and Karplus-Schplus based on CDV genome,and hydrophilicity,surface polarity plot and antigenic index were obtained by the methods of Kyte-Doolittle,Emini and Jameson-wolf respectively,combining the results according to these methods,the B cell epitopes for cap protein of CDV were predicted.The results showed that cap protein of CDV mi... |
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| Keywords: | CDV cap protein secondary structure B cell epitopes |
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