Effects of intrauterine growth restriction during late pregnancy on the ovine fetal renal function and antioxidant capacity |
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| Authors: | Yang Zi Chi Ma Huimin Li Suting Shen Yingchun Liu Ming Li Feng Gao |
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| Institution: | 1. College of Animal Science, Inner Mongolia Key Laboratory of Animal Nutrition and Feed Science, Inner Mongolia Agricultural University, Hohhot, China;2. College of Life Science, Inner Mongolia Key Laboratory of Biomanufacturing, Inner Mongolia Agricultural University, Hohhot, China |
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| Abstract: | This study investigated the effects of intrauterine growth restriction during late pregnancy on the ovine fetal renal function and renal antioxidant capacity. Eighteen ewes pregnant were randomly divided into control group (CG, ad libitum, 0.67 MJ ME·BW?0.75·day?1, n = 6), restricted group 1 (RG1, 0.18 MJ ME·BW?0.75·day?1, n = 6), and restricted group 2 (RG2, 0.33 MJ ME·BW?0.75·day?1, n = 6). At 140 days, the fetal blood, allantoic fluid and kidney tissue were collected to determinate fetal renal function and renal antioxidant capacity. The results showed that the fetal weight, kidney weight, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), aquaporin-2 (AQP-2) and aquaporin-3 (AQP-3), and total antioxidant capacity (T-AOC) in RG1 group were decreased compared with the CG (P < 0.05), but the contents of β2-Microglobulin (β 2-MG), cystatin C (Cys-C), filtered sodium excretion fraction (FENa), malondialdehyde (MDA), and hydroxyl radical (OH) in RG1 group were increased (P < 0.05). The impaired ovine fetal renal growth, antioxidant imbalance and dysfunction of glomerulus ultrafiltration, and the renal tubules reabsorption were induced by maternal malnutrition during late pregnancy. |
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| Keywords: | antioxidant imbalance fetal growth restriction glomerular ultrafiltration renal tubules reabsorb |
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