Anaplastic atypical myeloma with extensive cutaneous involvement in a dog |
| |
| Authors: | Fukumoto Shinya Hanazono Kiwamu Kawasaki Naomi Hori Yasutomo Higuchi Seiichi Sasaki Takushi Temma Kyosuke Uchide Tsuyoshi |
| |
| Institution: | Veterinary Internal Medicine, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan. |
| |
| Abstract: | A 7-year-old, male, mixed breed dog was referred to the Veterinary Teaching Hospital at Kitasato University because of anorexia, lameness and multiple cutaneous lesions. Observation of bone marrow plasmacytosis, osteolytic bone lesions, serum myeloma protein and cutaneous infiltration of myeloma cells led us to a diagnosis of multiple myeloma (MM) with cutaneous involvement. Polymerase chain reaction and sequence analysis for the rearranged genes of immunoglobulin and T-cell receptor demonstrated that the neoplastic cells found in skin lesions or bone marrow are of B-lymphocyte lineage and share a common original precursor cell. The dog was treated with UW-Madison protocol or melphalan/prednisone protocol and survived 175 days. This is rare case of anaplastic MM with cutaneous involvement in dog. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
