Liver X receptor activation and cholesterol efflux in macrophages from coronary atherosclerotic disease patients |
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| Authors: | QIAN Zong-jie ZENG Qiu-tang |
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| Institution: | Institute of Cardiology, Union Hospital, Tongji Medical College, Huangzhong University of Science & Technology, Wuhan 430022, China |
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| Abstract: | AIM:To study the characteristic of liver X receptor alpha (LXRα), it’s target gene expression and cholesterol efflux from human macrophages in coronary atherosclerotic disease (CAD) patients. METHODS:Human monocyte-derived macrophages from CAD patients and controls were collected. Before being detected apoA-I-mediated human monocyte-derived macrophage cholesterol efflux and LXRα and mRNA expression of its target gene, the macrophages were induced with or without TO-901317. 〖JP2〗RESULTS:Compared with control normal macrophage, the mRNA levels of LXRα and its target gene expression were changed, and the macrophage cholesterol efflux was decreased in CAD patients. After stimulationwith TO-901317, the reactive capacity of LXR was also decreased from human monocyte-derived macrophage of CAD patients. CONCLUSION:The changes of cholesterol efflux and some gene expression in macrophages may be the pathogenetic cause atherosclerosis, and macrophage LXR activity may offer potential therapeutic benefit in the treatment of CAD. |
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