Effects of PDS on TLR4 mRNA expression in cortex in endotoxic shock rats |
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| Authors: | WANG Jian-chun SUN Xiao-xia WANG Zhi YUAN Zhao-xin LIU Xiao SUN Lian-kun LI Yang ZHAO Xue-jian |
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| Institution: | 1.Research Center of Functional Experimental Sciences,2Department of Pathophysiology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China;3.Changchun Medical College, Changchun 130031, China |
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| Abstract: | AIM: To explore the molecular mechanism of brain tissue injury induced by endotoxin. METHODS: Rats were divided into LPS, LPS+DEX, LPS+PDS and control group, respectively. NOS activity, NO content and TLR4 mRNA expression were assayed 4 h after intravenous injection of LPS. RESULTS: NOS activity, NO content and TLR4 mRNA expression in LPS+DEX and LPS +PDS groups were obviously lower than those in LPS group. CONCLUSION: PDS may provide protective effects on the central nervous system by down-regulating TLR4 expression, reducing NOS activity and NO content in the brain tissue. |
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