| 黄曲霉毒素B2a的研究进展 |
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| 引用本文： | 罗胜军,谢光洪,李小兵,徐慧娟,姜涛,高英杰,王泽岩,王哲.黄曲霉毒素B2a的研究进展[J].中国畜牧兽医,2006,33(11):96-98. |
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| 作者姓名： | 罗胜军 谢光洪 李小兵 徐慧娟 姜涛 高英杰 王泽岩 王哲 |
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| 作者单位： | 1. 吉林大学畜牧兽医学院临床兽医系,长春,130062
2. 长春市动物疫病诊疗服务中心,长春,130062 |
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| 摘 要： | 黄曲霉毒素(aflatox in,AFT)是一类有毒致癌化合物,污染粮食及其制品,给人类及动物健康造成严重威胁。AFB2a是AFT的一种,作者对AFB2a的毒性、生物学活性及其抗体的反应性进行了综述。由于AFB2a的毒性远远低于AFB1,而且AFB2a抗体能与AFB1及其在体内的代谢产物发生免疫学交叉反应,因此AFB2a的抗体,尤其是单克隆抗体对人、畜AFT中毒病的早期诊断、治疗、AFB1在体内的代谢转归、肿瘤预防以及食品卫生监测有着非常重要的意义,而有关AFB2a的单克隆抗体方面的研究,国内还未见报道。
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| 关 键 词： | 黄曲霉毒素 黄曲霉毒素B2a 研究进展 |
| 文章编号： | 1671-7236（2006）11-0096-03 |
| 收稿时间： | 2006-02-21 |
| 修稿时间： | 2006年2月21日 |
Development Studies of Aflatoxin B2a |
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| LUO Sheng-jun,XIE Guang-hong,LI Xiao-bing,XU Hui-juan,JIANG Tao,GAO Ying-jie,WANG Zhe-yan,WANG Zhe.Development Studies of Aflatoxin B2a[J].China Animal Husbandry & Veterinary Medicine,2006,33(11):96-98. |
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| Authors: | LUO Sheng-jun XIE Guang-hong LI Xiao-bing XU Hui-juan JIANG Tao GAO Ying-jie WANG Zhe-yan WANG Zhe |
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| Institution: | 1. College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China; 2. Changchun Diagnosis and Treatmat Conter of Animal Diseases,Changchun 130062,China |
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| Abstract: | Aflatoxin is a kind of toxic and carcinogen compound,which polluted rice and products.It is serious harmfulness to the health of experimenter,human being and animal.Aflatoxin B_(2a) is a kind of the aflatoxin.This essay summarized the toxicity and biological activity of AFB_(2a) and reactivity of antibody.As the toxicity of AFB_(2a) was lower than AFB_1,and the antibody can act on AFB_1,AFB_1-DNA adducts and related metabolites,so the broad specincity AFB_(2a) antibody might be of considerable value in the detection of AFB_1-DNA adducts or related metabolites,prevent tumor?discarding toxic of rice and it's products and the prophase diagnose of aflatoxicosis.But the reporting about AFB_(2a) Monoclonal antibody was absence in China. |
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| Keywords: | aflatoxin aflatoxin B_(2a) research advance |
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