Toxicology of insecticides to mammals |
| |
| Authors: | Timothy C Marrs |
| |
| Institution: | Edentox Associates, Edenbridge, Kent, UK. timothymarrs05@aol.com. |
| |
| Abstract: | Many insecticides target structures or functions in non-target species, including mammals. This is particularly true of those that target the insect nervous system, such as the organochlorines, anticholinesterases and GABA antagonists. Another group of insecticides target structures or functions not present in mammals, and this group of insecticides has considerable target species specificity, but there are often potential targets in mammals. Octopamine is closely related to adrenaline and amitraz (an octopamine receptor agonist) and acts in mammals at α2-adrenergic receptors. Although there are potential targets in mammals for juvenile hormone mimics and ecdysone receptor agonists, there is no evidence that the mammalian toxicity of either group is related to their insecticidal activity. Nor do chitin synthesis inhibitors have high mammalian toxicity. Copyright © 2012 Society of Chemical Industry |
| |
| Keywords: | insecticide pesticide insect mammal toxicity toxicology |
| 本文献已被 PubMed 等数据库收录！ |
|
