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鸡球虫早熟株的生物学特性及其在疫苗中的应用
引用本文:韩静芳,董辉,俞纯方,黄兵.鸡球虫早熟株的生物学特性及其在疫苗中的应用[J].中国兽医寄生虫病,2006,14(4):37-41.
作者姓名:韩静芳  董辉  俞纯方  黄兵
作者单位:1. 西南大学动物科技学院,北碚,400715;中国农业科学院上海兽医研究所,农业部动物寄生虫重点开放实验室,上海,200232
2. 中国农业科学院上海兽医研究所,农业部动物寄生虫重点开放实验室,上海,200232
3. 西南大学动物科技学院,北碚,400715
基金项目:科技部科技基础条件平台建设计划;中国科学院所长基金
摘    要:按照Jeffers建立的艾美耳球虫早熟株选育方法选育出的球虫早熟株,其潜在期明显缩短,繁殖力和致病性显著降低,但保持良好的免疫原性.并且,早熟株的弱毒性和早熟性具有遗传稳定性,通过放松选择压力反复传代后无恢复现象。国内外学者根据早熟株的这些生物学特性,并在深入了解鸡球虫病的保护性免疫机制的基础之上研制了抗鸡球虫病的早熟株弱毒活苗。本文综述了球虫早熟株的生物学特性,并介绍了目前国内外研制出的球虫早熟苗在鸡球虫病防治方面的应用。

关 键 词:鸡球虫  早熟株  生物学特性  早熟苗
文章编号:1005-0868(2006)04-0037-05
收稿时间:2006-03-20
修稿时间:2006年3月20日

CHARACTERISTICS OF COCCIDIA PRECOCIOUS STRAIN AND THE APPLICATION OF VACCINES
HAN Jing-fang,DONG Hui,YU Chun-fang,HUANG Bing.CHARACTERISTICS OF COCCIDIA PRECOCIOUS STRAIN AND THE APPLICATION OF VACCINES[J].Chinese Journal of Veterinary Parasitology,2006,14(4):37-41.
Authors:HAN Jing-fang  DONG Hui  YU Chun-fang  HUANG Bing
Institution:1. College of Animal Science and Technology, Southwest University, Beibei Chongqing 400715 ; 2. Shanghai Veterinary Research Institute, CAAS, Key Laboratory for Animal Parasitology of Ministry of Agriculture, Shanghai 200232, China
Abstract:Precocious strain of coccidia was selected by passing the parasite in chickens as described by Jeffers.Compared with the parental strain,the precocious strain had the following characteristics:the prepatent period was shortered,the reproductive capacity and the pathogenicity was decreased,but it remains much of the immunogenicity of the parental strain.The characteristics of the precocious strain is genetically stable and can't reinstate by relaxing the selection pressures.On the basis of the characteristics of precocious strain,and in-depth understanding of chicken coccidiosis protective immune mechanisms,domestic and foreign scholars developed the anti-chicken coccidiosis precocious attenuation vaccine.This article provides an overview of the characteristics of coccious strain,and introduced the applications of the coccidia attenuation vaccine that were developed by scholars in domestic and international.
Keywords:Coccidia  precocious strain  characteristics  vaccine
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