A Preliminary Study on the Anthelmintic Activity of Calotropis procera Latex against Haemonchus contortus Infection in Najdi Sheep |
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| Authors: | Al-Qarawi AA Mahmoud OM Sobaih MA Haroun EM Adam SEI |
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| Institution: | (1) Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, PO Box 1482, Buraydah, Al-Qassim, Saudi Arabia |
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| Abstract: | The anthelmintic activity of Calotropis procera latex was investigated in sheep that had been infected with single oral doses of 12 000 infective Haemonchus contortus larvae. Inappetence, dullness, erosive abomasitis, decreased haemoglobin concentration and increased eosinophils were the main features of haemonchosis in the sheep. In the sheep treated with single oral doses of 0.01 ml or 0.02 ml/kg body weight of C. procera latex, egg production was significantly reduced, but not completely suppressed, and fewer adult Haemonchus worms were found in the abomasum. Although the appetite improved, the haemoglobin concentration and serum copper, iron and zinc levels were still reduced after therapy with Calotropis latex. Calotropis latex showed a concentration-dependent larvicidal activity in vitro within 20 min of application. |
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| Keywords: | anthelmintic Calotropis procera efficacy Haemonchus larvicide latex sheep |
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