| 寄生虫半胱氨酸蛋白酶研究进展 |
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| 引用本文： | 宋军科,才学鹏,骆学农,林青,窦永喜,于三科.寄生虫半胱氨酸蛋白酶研究进展[J].动物医学进展,2011(12):95-98. |
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| 作者姓名： | 宋军科 才学鹏 骆学农 林青 窦永喜 于三科 |
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| 作者单位： | 西北农林科技大学动物医学院;中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室甘肃省动物寄生虫病重点实验室 |
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| 基金项目： | 国家高科技研究发展计划“863”(2006AA10A207) |
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| 摘 要： | 半胱氨酸蛋白酶(Cysteine protease,CP)是一类在酶的活性中心含有半胱氨酸残基的蛋白水解酶.CP属于木瓜蛋白酶家族,广泛分布于从病毒至脊椎动物的生物体中.对人体半胱氨酸蛋白酶的研究主要集中在细胞凋亡分子机制和恶性肿瘤的基因诊断与治疗等方面.而对寄生虫半胱氨酸蛋白酶研究的内容则更为广泛,其中包含半胱氨酸蛋...
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| 关 键 词： | 寄生虫 半胱氨酸蛋白酶 生物学特性 |
Progress on Cysteine Protease in Parasites |
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| SONG Jun-ke,CAI Xue-peng,LUO Xue-nong,LIN Qing,DOU Yong-xi,YU San-ke.Progress on Cysteine Protease in Parasites[J].Progress In Veterinary Medicine,2011(12):95-98. |
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| Authors: | SONG Jun-ke CAI Xue-peng LUO Xue-nong LIN Qing DOU Yong-xi YU San-ke |
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| Institution: | 1 (1 College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi,712100,China;2.China Key Laboratory of Veterinary Parasitology of Gansu Province,State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,CAAS,Lanzhou,Gansu,730046,China) |
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| Abstract: | Cysteine protease(CP) is a kind of protein hydrolase which has cystein residues in the active center of the enzyme.CP belongs to the papain family and widely distributes from viruses to vertebrates.The study of cysteine protease mainly focuses on the molecular mechanism of cell apoptosis,the gene diagnosis and treatment of malignant in human.But,the research content of cysteine protease is much more extensive in parasites.The study included cysteine proteases in parasite immune evasion,virulence,tissue invasion,molting and cyst formation,hatching and so on.The studies showed that the enzyme has host specificity,and can be used as a diagnostic antigen and candidate vaccine molecule for parasitic disease.At the same time,the enzyme is also a target for drug treatment in parasitic diseases.The paper reviewed the recent progress on the cysteine protease in parasites. |
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| Keywords: | parasite cysteine protease biological characeristic |
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